Meta-analysis of Efficacy and Safety of Bifid Triple Viable Capsule Combined With Quadruple Therapy for Helicobacter pylori Infection
10.3969/j.issn.1008-7125.2023.12.002
- VernacularTitle:双歧杆菌三联活菌联合四联疗法对幽门螺杆菌感染疗效和安全性的meta分析
- Author:
Yanjie SHEN
1
;
Lu SUN
;
Zhou XU
;
Bin LÜ
Author Information
1. 浙江中医药大学附属第一医院(浙江中医药大学第一临床医学院)消化内科(310006)
- Keywords:
Bifid Triple Viable Capsule;
Quadruple Therapy;
Helicobacter pylori;
Meta-Analysis
- From:
Chinese Journal of Gastroenterology
2023;28(12):710-716
- CountryChina
- Language:Chinese
-
Abstract:
Background:With the increasing incidence of antibiotic resistance and adverse reactions to Helicobacter pylori(Hp),it is difficult for proton pump inhibitor-based quadruple therapy to meet the actual clinical treatment needs,so it is necessary to seek another effective combination therapy program on this basis.In recent years,the application of microecological preparations represented by Bifid triple viable capsule has been widely valued in clinical practice with its unique advantages.Aims:To evaluate the efficacy and safety of Bifid triple viable capsule combined with quadruple therapy in the treatment of Hp infection.Methods:The databases of CNKI,Wanfang,VIP,CBM,PubMed,Web of Science from January 2012 to April 2023 were searched by computer,to collect the relevant literature published at home and abroad on the treatment of Hp infection with Bifid triple viable capsule combined with quadruple therapy,and to screen the included literature for quality evaluation using the Cochrane risk bias tool,and to extract relevant data.Data were Meta-analyzed with RevMan 5.4.Results:Ten randomized controlled trials were included,including 1 828 patients with or without underlying disease who were Hp positive.Meta-analysis showed that the eradication rate of Hp in Bifid triple viable capsule combined with quadruple therapy was significantly higher than that in quadruple therapy group(RR=1.23,95%CI:1.19-1.29,P<0.000 01),while the incidence of adverse reactions was significantly decreased(RR=0.37,95%CI:0.28-0.48,P<0.000 01).Conclusions:Bifid triple viable capsule combined with quadruple therapy can significantly increase the eradication rate of Hp and reduce the adverse drug reactions,which has practical significance to guide clinical application.
