Regulatory Mechanism of NCOA4-mediated Ferritinophagy and its Progress in Colitis and Colitis-associated Cancer
10.3969/j.issn.1008-7125.2023.10.007
- VernacularTitle:NCOA4介导铁自噬的调控机制及其在结肠炎和结肠炎相关癌症中的研究进展
- Author:
Dan ZHANG
1
;
Qiqi HUANG
;
Hongna LI
;
Li LIU
;
Huirong LIU
;
Xiaopeng MA
Author Information
1. 上海市针灸经络研究所(200030)
- Keywords:
Ferroptosis;
Ferritinophagy;
NCOA4;
Colitis;
Colitis-Associated Cancer
- From:
Chinese Journal of Gastroenterology
2023;28(10):620-625
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal iron metabolism mediated by ferritinophagy is one of the most important mechanisms in the occurrence of ferroptosis.The regulatory mechanism of ferritinophagy mainly involves the transcription of NCOA4 and its corresponding protein modifications.Ferroptosis plays an important role in the development of colitis and colitis-associated cancer,and target-oriented regulation of ferroptosis can alleviate colonic inflammatory response and induce the tumor cell death.This article mainly reviewed the regulatory mechanism of NCOA4-mediated ferritinophagy and its progress in colitis and colitis-related cancer,which may provide a new point for the investigation on mechanism of colitis and inflammation-cancer transformation.
