Relationship Between Preoperative Inflammatory Markers,Fibrinogen,Apolipoprotein B and Lymph Node Metastasis in Early Colorectal Cancer
10.3969/j.issn.1008-7125.2023.09.002
- VernacularTitle:早期结直肠癌术前炎症指标、纤维蛋白原、载脂蛋白B与淋巴结转移的关系
- Author:
Xu SONG
1
;
Jun LI
;
Yuhang ZHOU
;
Zikun WANG
;
Yunfei KONG
;
Jiang ZHU
;
Jin ZHANG
Author Information
1. 江苏大学附属医院普外科(212000)
- Keywords:
Early Colorectal Neoplasms;
Lymph Node Metastasis;
Preoperative Inflammation Markers;
Fibrinogen;
Apolipoprotein B
- From:
Chinese Journal of Gastroenterology
2023;28(9):523-528
- CountryChina
- Language:Chinese
-
Abstract:
Background:With the improvement of national health awareness and the popularization of a series of screening methods,the number of early colorectal cancer is gradually increasing,accurate prediction of lymph node metastasis of T1 colorectal cancer is the key to determine the optimal therapeutic solutions.Aims:To investigate the relationship between preoperative inflammatory markers,fibrinogen,apolipoprotein B and lymph node metastasis in patients with early colorectal cancer.Methods:The clinical data of 102 patients with early colorectal cancer who received surgical treatment in the Department of General Surgery,Affiliated Hospital of Jiangsu University from January 2014 to December 2022 were retrospectively analyzed.The patients were divided into positive lymph node group and negative lymph node group according to postoperative pathological results.Univariate and multivariate Logistic regression analysis were employed to explore the correlation between lymph node metastasis and clinical test parameters in early colorectal cancer.Results:A total of 102 patients in T1 colorectal cancer were enrolled in this study,including 53 males and 49 females,and the mean age was(64±10)years.Postoperative pathological diagnosis of lymph node metastasis was 13 cases and no lymph node metastasis was 89 cases.The univariate analysis showed that age,fibrinogen and apolipoprotein B-monocyte ratio(AMR)were related to lymph node metastasis in early colorectal cancer(P<0.05).The multivariate Logistic regression analysis showed that age,fibrinogen and AMR were independent predictors of lymph node metastasis.Conclusions:The age,fibrinogen and AMR may play an important role in predicting lymph node metastasis in early colorectal cancer.They can be combined with pathological factors to further create a new prediction model,so as to provide some reference for patients in colorectal cancer to choose the therapeutic regimen.
