Research Progress on Metabolic Mechanism of Ferroptosis and its Role in Ulcerative Colitis
10.3969/j.issn.1008-7125.2023.08.009
- VernacularTitle:铁死亡的代谢机制及其在溃疡性结肠炎中作用的研究进展
- Author:
Cheng CHENG
1
,
2
;
Jingyi HU
;
Lei ZHU
;
Hong SHEN
Author Information
1. 南京中医药大学附属医院(210029)
2. 南京中医药大学
- Keywords:
Ferroptosis;
Metabolism;
Colitis,Ulcerative
- From:
Chinese Journal of Gastroenterology
2023;28(8):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of cell death with iron dependence,which has been confirmed to play an important role in the pathophysiology of various diseases.This review summarizes the main metabolic pathways of ferroptosis,including iron metabolic pathways,lipid metabolic pathways and the classic GSH/GPX4 metabolic pathways.At the same time,this review discusses the regulatory effect and mechanism of ferroptosis metabolism on ulcerative colitis,aiming to provide new ideas and research directions for the treatment of ulcerative colitis.
