Origin of Spasmolytic Polypeptide Expressing Metaplasia and its Relationship With Repair of Gastric Mucosal Injury and Gastric Cancer
10.3969/j.issn.1008-7125.2023.08.008
- VernacularTitle:解痉多肽表达化生的起源及其与胃黏膜损伤修复和胃癌发生的关系
- Author:
Qiqi GUO
1
;
Yongquan SHI
Author Information
1. 西安医学院(710021)
- Keywords:
Spasmolytic Polypeptide Expressing Metaplasia;
Animal Model;
Gastric Mucosal Injury;
Helicobacter pylori;
Stomach Neoplasms;
Gastric Precancerous Lesion
- From:
Chinese Journal of Gastroenterology
2023;28(8):499-503
- CountryChina
- Language:Chinese
-
Abstract:
Spasmolytic polypeptide expressing metaplasia(SPEM)is a kind of metaplasia of gastric mucosa.There are three hypotheses of its origin,including chief cell transdifferentiation,stem cell differentiation,and pre-SPEM hypotheses.Currently,animal models are commonly used for the mechanism research.According to results of the researches,SPEM plays a role in the repair of gastric mucosal damage,Helicobacter pylori infection and the development of gastric cancer.This paper provides an overview of the above issues and the multiple ways of modeling the SPEM.
