Correlation Between Preoperative Nutritional/Inflammatory-related Indicators and Prognosis in Patients Undergoing Radical Surgery for Colorectal Cancer
10.3969/j.issn.1008-7125.2023.07.002
- VernacularTitle:术前营养/炎性相关指标与结直肠癌根治术患者预后的关系
- Author:
Ge OU
1
;
Danling HE
;
Kaiqiang XIE
;
Jie GE
Author Information
1. 湖南省人民医院 湖南师范大学附属第一医院药学部(410002)
- Keywords:
Colorectal Neoplasms;
Nutrition Indicators;
Inflammation Indicators;
Prognosis
- From:
Chinese Journal of Gastroenterology
2023;28(7):390-397
- CountryChina
- Language:Chinese
-
Abstract:
Background:Nutritional status and inflammatory indicators in patients with gastrointestinal tumors have a significant impact on patient prognosis.Aims:To investigate the association between preoperative nutritional/inflammation-related indicators and the prognosis of colorectal cancer patients underwent radical surgery,and to identify valuable prognostic assessment indicators.Methods:Colorectal cancer patients underwent radical surgery from 2018 to 2020 were enrolled,and a patient cohort was established.Clinical data were collected,correlation of preoperative nutritional/inflammation-related indicators with prognosis were analyzed,and predictive nutritional/inflammation-related indicators were screened.Results:A total of 146 patients were collected in this study.The results of Cox proportional risk model univariate analysis showed that family history of tumor,TNM staging,CEA,AGR,PLR,and SII were significantly associated with survival(P<0.05).Multivariate analysis revealed that preoperative AGR(HR=0.227,95%CI:0.087-0.595;P=0.003),NLR(HR=2.472,95%CI:1.058-5.778;P=0.037),PLR(HR=2.692,95%CI:1.162-6.235;P=0.021)and SII(HR=5.237,95%CI:1.857-14.771;P=0.002)were associated with prognosis of colorectal cancer patients,and AGR had the best prognostic ability.Conclusions:Four preoperative nutritional/inflammatory indicators,AGR,NLR,PLR,and SII,are associated with prognosis of colorectal cancer patients underwent radical surgery.
