Fecal Microbiota Transplantation for Ulcerative Colitis:An Overview of Systematic Review/meta-analysis
10.3969/j.issn.1008-7125.2023.06.003
- VernacularTitle:粪菌移植治疗溃疡性结肠炎系统评价/meta分析的再评价
- Author:
Xueqing GONG
1
;
Tongting LIU
;
Lanxin FAN
Author Information
1. 山东中医药大学第一临床医学院1(250014)
- Keywords:
Fecal Microbiota Transplantation;
Colitis,Ulcerative;
Systematic Review/Meta-Analysis;
Report Quality;
Methodological Quality;
Evidence Quality
- From:
Chinese Journal of Gastroenterology
2023;28(6):335-343
- CountryChina
- Language:Chinese
-
Abstract:
Background:The morbidity of ulcerative colitis(UC)is high,and is easily recurrent.A number of systematic review/meta-analysis have explored the efficacy and safety of fecal microbiota transplantation(FMT)in the treatment of UC with varying conclusions,however,the quality of these studies has not yet been adequately assessed.Aims:To overview the systematic review/meta-analysis of FMT for UC.Methods:Systematic review/meta-analysis of FMT in the treatment of UC were retrieved from PubMed,Cochrane Library,Embase,Web of Science,CNKI,CBM,Wanfang,VIP and other databases from the date of database establishment to May 2023,while gray literatures were searched and experts were consulted.Literature screening and extract information were performed by two researchers.The PRISMA checklist,AMSTAR-2 tool was used to assess the reporting quality and methodological quality,respectively,as well as to grade the quality of evidence for outcome measurements based on the GRADE system.Results:Seventeen systematic review/meta-analysis were finally included.The original studies included randomized controlled trials and observational studies.Most of the studies drew positive conclusions about the efficacy and safety of FMT in the treatment of UC.The PRISMA checklist score was 12.5-22.5,and the mean score was 17.68.Three studies reported relative completeness;ten had some deficiencies;and four had relatively serious report deficiencies.AMSTAR-2 tool showed that two were of intermediate quality,three were of low quality,and twelve were of very low quality.GRADE system ratings showed that six of the eight outcome measurements were of intermediate quality and two were of low quality.Conclusions:FMT may be a safe and effective treatment for UC,but the quality of the current evidence is low and users of clinical evidence need to treat the above evidence with caution.
