Advances in Research on Duodenal Inflammation and Overlapping Symptoms of Functional Gastrointestinal Disorders
10.3969/j.issn.1008-7125.2023.02.009
- VernacularTitle:十二指肠炎症与功能性胃肠病症状重叠的研究进展
- Author:
Zhiwei HUANG
1
;
Xiujuan YAN
;
Shengliang CHEN
Author Information
1. 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所(200001)
- Keywords:
Functional Gastrointestinal Disorders;
Overlapping Symptoms;
Duodenal Inflammation;
Eosinophils;
Mast Cells;
Gut-Brain Interaction
- From:
Chinese Journal of Gastroenterology
2023;28(2):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Overlapping symptoms are common in functional gastrointestinal disorders(FGIDs).The treatment of FGIDs is based on promoting gastrointestinal motility and improving visceral hypersensitivity,however,the efficacy is limited.Emerging data suggest the presence of low-grade duodenal inflammation with predominant eosinophilic infiltration in functional dyspepsia(FD)patients,accompanied by impaired epithelial barrier,increased permeability and increased pyroptosis,etc.,especially in FD patients overlapping gastroesophageal reflux disease(GERD)and/or irritable bowel syndrome(IBS).The etiologies of FGIDs include infection,stress,food antigens,irregular diet etc.,and can increase mucosal permeability,involve in the gut-brain interaction via activating duodenal mucosal eosinophil-mast cell axis,thus causing the symptoms of FGIDs as well as the overlapping symptoms.This article reviewed advances in research on duodenal inflammation and overlapping symptoms of FGIDs.
