Analysis of the Role of Pepsin in Vocal Cord Polyp and Vocal Cord Cancer
10.3969/j.issn.1006-7299.2024.01.005
- VernacularTitle:胃蛋白酶在声带息肉、声带癌中的作用分析
- Author:
Jingyu GAO
1
;
Renjing LUO
;
Biao RUAN
;
Chaowu JIANG
;
Zhuohui LIU
;
Ruiqing LONG
;
Qiulin LIANG
;
Ce ZHANG
;
Lu SU
;
Peng LI
Author Information
1. 昆明医科大学第一附属医院耳鼻咽喉科(昆明 650032)
- Keywords:
Vocal cord polyp;
Vocal cord cancer;
Pepsin
- From:
Journal of Audiology and Speech Pathology
2024;32(1):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of pepsin in vocal cord polyps and vocal cord cancer,and to compare the difference of pepsin expression.Methods From May 2020 to December 2021,27 patients with vocal cord polyp,27 patients with vocal cord cancer and 23 healthy volunteers were selected.RSI and RFS scoring scales were used for scoring,pepsin detection kit was used for saliva pepsin detection,and immunohistochemical methods were used to detect the expression of pepsin in vocal cord tissues of patients with vocal cord polyps and vocal cord cancer.Results The RSI score,RFS score and pepsin test kit results of vocal cord polyp group and vocal cord canc-er group were higher than those of non-vocal cord disease group,and the differences of the three indexes were statis-tically significant(P＜0.05).RSI score,pepsin detection kit results and pepsin immunohistochemistry results of vocal cord polyp group showed no significant difference compared with vocal cord cancer group(P＞0.05).The RFS score of vocal cord polyp group was significantly different from that of vocal cord cancer group(P＜0.05).Conclusion Pepsin may be an important pathogenic factor of vocal cord polyp and vocal cord cancer,and play an im-portant role in the occurrence of these two diseases.The difference of pepsin expression in vocal cord polyp and vo-cal cord cancer suggests that pepsin may have different pathogenesis.
