Research progress of RNA m6A methylation in post-stroke cognitive impairment
10.11958/20230780
- VernacularTitle:RNA m6A甲基化在卒中后认知障碍中的研究进展
- Author:
Yuqian XIAO
1
;
Kexin SUN
;
Jun WAN
;
Shuying CHEN
;
Limin CHEN
;
Yan WANG
;
Yanjie BAI
Author Information
1. 河南中医药大学(邮编 450000)
- Keywords:
stroke;
cognition disorders;
inflammation;
microglia;
astrocytes;
m6A methylation
- From:
Tianjin Medical Journal
2024;52(3):331-336
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke cognitive impairment(PSCI)is mainly manifested as learning and memory disorders.Highly enriched RNA m6A methylation modification in mammalian brain is involved in glial cell-mediated neuroinflammation.Given that neuroinflammation is the main mechanism for neural damage and spatial and memory impairment of PSCI,it is speculated that RNA m6A methylation modification can regulate the inflammatory response of glial cells after stroke to improve PSCI.This review summarizes and analyzes the role of RNA m6A methylation modification in the development of PSCI and analyzes its detailed mechanism of regulating glial cell-mediated inflammation,which will provide reference for researchers in this field.
