Research progress of cerebral organoid technology and its application in stroke treatment
10.11958/20231381
- VernacularTitle:脑类器官技术及在脑卒中治疗中的应用进展
- Author:
Kexin SUN
1
;
Yuqian XIAO
;
Jun WAN
;
Shuying CHEN
;
Limin CHEN
;
Yan WANG
;
Yanjie BAI
Author Information
1. 河南中医药大学(邮编 450000)
- Keywords:
organoids;
transplantation;
microchip analytical procedures;
stroke;
cerebral organoid
- From:
Tianjin Medical Journal
2024;52(1):38-43
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral organoids are three-dimensional nerve cultures induced by embryonic stem cells(ESCs)or induced pluripotent stem cells(iPSCs)that mimic the structure and function of human brain.With the continuous optimization of cerebral organoid culture technology and the combination with emerging technologies such as organ transplantation,gene editing and organoids-on-chip,complex brain tissue structures such as functional vascular structures and neural circuits have been produced,which provides new methods and ideas for studying human brain development and diseases.This article reviews the latest advances in brain organoid technology,describes its application in neurological diseases and advances in stroke modeling and transplantation treatment.
