Clinical features and risk factors of chronic persistent asthma small airway dysfunction
- VernacularTitle:慢性持续期支气管哮喘小气道功能障碍的临床特征及危险因素分析
- Author:
Chenhui PAN
1
;
Yu WANG
;
Zifeng MA
;
Dingzhong WU
;
Shaoyan ZHANG
;
Lei QIU
;
Zhenhui LU
Author Information
- Keywords: asthma; respiratory tract diseases; risk factors; ROC curve; small airway dysfunction
- From: Tianjin Medical Journal 2023;51(12):1365-1369
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the clinical characteristics and risk factors of small airway dysfunction(SAD)in patients with asthma.Methods The clinical data of 200 patients with chronic persistent asthma were included,including general data,disease-related condition,pulmonary function test result,compliance assessment and asthma control status.The clinical features of the two groups were compared.Logistic regression was used to analyze risk factors for asthma SAD,and ROC curves were plotted to assess the predictive power of the model.Results Two hundred patients were divided into the SAD group(128 cases)and the non-SAD group(72 cases).The main risk factors of SAD in patients with chronic persistent asthma included smoking history(OR=4.758,95%CI:2.043-11.081),overweight(OR=2.952,95%CI:1.428-6.105),asthma without clinical remission(OR=6.140,95%CI:2.929-12.870),acute asthma attack in recent 1 year(OR= 3.406,95%CI:1.430-8.117)and allergic rhinitis(OR=2.289,95%CI:1.121-4.673).The area under the curve(AUC)of above risk factors were 0.612,0.610,0.716,0.614 and 0.600,respectively.The AUC of the composite prediction model was 0.826(95%CI:0.769-0.883),which had good prediction value.Conclusion Smoking,overweight,acute asthma attack in recent one year,non-remission period of asthma and allergic rhinitis are independent risk factors for SAD in chronic persistent asthma.The risk factors of SAD should be identified as early as possible,and individualized monitoring and treatment should be taken.
