Research Progress of Non-coding RNA in Autophagy of Macrophages During Mycobacterium tuberculosis Infection

VernacularTitle:非编码RNA调控结核分枝杆菌感染巨噬细胞自噬的研究进展
Author: Xianglin PENG ¹ ; Feifei PU ; Jing FENG
Author Information

1. 华中科技大学同济医学院附属武汉市中西医结合医院骨科,武汉 430022
Keywords: tuberculosis; Mycobacterium tuberculosis; non-coding RNA; macrophage; autophagy
From: Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2024;53(1):117-122
CountryChina
Language:Chinese
Abstract: Tuberculosis(TB)is an infectious disease caused by Mycobacterium tuberculosis(MTB).Autophagy plays an im-portant role in eliminating MTB which can interfere with host autophagy through a variety of mechanisms,therefore,escape the killing of macrophages to survive and reproduce in the host cells for a long time.There are many kinds of differential expressed non-coding RNAs(ncRNAs)in macrophages upon MTB infection.These ncRNAs can affect the elimination of MTB by regula-ting the expression of autophagy-related genes in multiple processes of autophagy.Elucidating these regulatory networks are of great significance for the development of new anti-TB drugs.Therefore,the known mechanisms of ncRNAs that regulates the autophagy of MTB infected macrophages were summarized,and the process of autophagy and the main regulatory functions of ncRNAs were introduced in this review,in order to provide new perspectives for the pathogenesis of TB and the development of anti-TB drugs.