Application of Single Cell RNA Sequencing in Glioblastoma Research
10.3870/j.issn.1672-0741.22.12.029
- VernacularTitle:单细胞RNA测序技术在胶质母细胞瘤研究中的应用
- Author:
Ping SONG
1
;
Hui DENG
;
Mengxian ZHANG
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤科,武汉 430022
- Keywords:
single-cell RNA sequencing;
tumor heterogeneity;
immune microenvironment;
treatment strategy
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(1):110-116
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma is the most common primary malignant tumor of brain in adults.Although great efforts have been made to improve prognosis in recent years,the median survival is still less than 20 months,and less than 5％of patients survive longer than 20 months.The standard treatment is maximum surgical excision combined with radiotherapy and temozolomide chemotherapy.Single cell RNA sequencing(scRNA-seq)technology accurately analyzes each unique cell,enabling us to better understand the heterogeneity of tumors,the evolution process of tumor cells,the special functions of various types of cells in the immune microenvironment,and the interactions between cells,thus providing new ideas for personalized clinical therapy.This review focuses on the application of scRNA-seq in the study of glioblastoma heterogeneity,tumor immune microenvironment,cell communication and treatment.
