Current Proceedings in Ascl1 Induced Reprogramming Neurons
10.3870/j.issn.1672-0741.22.10.020
- VernacularTitle:转录因子Ascl1诱导体细胞重编程为神经元的研究进展
- Author:
Yingdan ZHANG
1
;
Li CHEN
Author Information
1. 广西医科大学第一附属医院神经内科,南宁 530021
- Keywords:
Ascl1;
cell reprogramming;
induced neuron
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2023;52(6):873-877
- CountryChina
- Language:Chinese
-
Abstract:
The transcription factor Ascl1 can reprogram fibroblasts,astrocytes,Muller glial cells and other somatic cells in-to multiple subtypes of induced neurons,including dopaminergic neurons,amino acid neurons,etc.The complex mechanism in-volved in this process includes hierarchical mechanism and changes in transcription level.This article reviews the research on re-programming of somatic cell into neurons induced by Ascl1.
