Research Progress of Cell Senescence in Preeclampsia
10.3870/j.issn.1672-0741.23.03.010
- VernacularTitle:细胞衰老在子痫前期中的研究进展
- Author:
Yang ZHANG
1
;
Yanqi ZHONG
;
Li ZOU
Author Information
1. 华中科技大学同济医学院附属协和医院妇产科,武汉 430022
- Keywords:
cell senescence;
preeclampsia;
placenta;
anti-aging drug
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2023;52(6):868-872
- CountryChina
- Language:Chinese
-
Abstract:
A well-developed placenta is the prerequisite for fetal development in utero while the placental dysplasia is the pathological basis of multiple pathological pregnancy,such as preeclampsia.Cell senescence is an irreversible state of cell cycle arrest.There is physiological senescence of the placenta in the progress of normal pregnancy.A variety of adverse factors can ac-celerate the pathological senescence of the placenta,resulting in placental dysplasia and dysfunction,and then induce multiple placental diseases such as preeclampsia.Recent studies have found that a variety of natural or synthetic anti-aging drugs also show a satisfying effect in preeclampsia disease models,suggesting that targeted cell senescence may be a potential mechanism for the treatment of preeclampsia.In this article,the latest literature was reviewed in terms of research status of cell senescence in the pathogenesis of preeclampsia.
