Clinical Characteristics and Surgical Results for Patients with Asymptomatic Meningioma
10.3870/j.issn.1672-0741.22.09.012
- VernacularTitle:无症状脑膜瘤的临床特征及手术治疗
- Author:
Lingcheng ZENG
1
;
Hua LI
;
Rudong CHEN
Author Information
1. 华中科技大学同济医学院附属同济医院神经外科,武汉 430030
- Keywords:
asymptomatic meningioma;
clinical characteristics;
surgery;
prognosis
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2023;52(6):847-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical features of asymptomatic meningioma patients and evaluate the factors re-lated to surgical complications and prognosis,and to provide evidence for screening asymptomatic meningioma patients suitable for early surgical intervention.Methods The medical records of meningioma patients who underwent surgery from January 1st 2015 to December 31st 2020 at Neurosurgery Department of Tongji Hospital Affiliated to Tongji Medical College were retro-spectively reviewed.The clinical characteristics were compared between symptomatic and asymptomatic meningioma.Factors re-lated to the effects of surgery,postsurgical complications or patient prognosis were analyzed through Chi-squared test and multi-variate binary Logistic regression analysis.Results Elder age(HR:2.042;95％CI:1.002-4.098;P=0.021),smaller tumor size(HR:1.666;95％CI:1.009-3.857;P=0.014),intracranial superficial location(HR:2.221;95％CI:1.236-3.994;P=0.008)and no peritumoral brain edema(HR:8.917;95％CI:5.028-15.813;P＜0.01)were significant features of asymptomat-ic meningioma compared to those of symptomatic ones.The benefit of early surgery for asymptomatic meningioma was the a-chievement of higher total resection rate(88.6％)(P=0.035).Among the total resection cases,72％located in the intracranial superficial area,while merely 28％located in the intracranial deep area.Ninety-two percent of asymptomatic patients had re-turned to normal work and life at 6 months after operation.A parietal location was a significant factor indicating postsurgical complications(HR:3.351;95％CI:1.258-11.355;P=0.024),while elder age(≥60 years old)(HR:0.875;95％CI:0.825-0.999;P=0.041)was a significant factor indicating poor patient prognosis.Conclusion Asymptomatic meningioma is more common in elderly patients,usually located superficially in cranial cavity,with smaller size and without peritumoral edema.A more prominent total resection rate can be achieved in this type of meningioma.An early surgical resection would be recommen-ded as a proper treatment strategy.Tumor site and age are potential indicators for predicting postoperative complications and prognosis of patients.Comprehensive evaluation should be consider before surgery.
