Research progress on the bone marrow microenvironment in the pathogenesis of leukemia
10.11904/j.issn.1002-3070.2023.06.012
- VernacularTitle:骨髓微环境在白血病发病机制中的研究进展
- Author:
Li WANG
1
;
Kejin WANG
Author Information
1. 成都上锦南府医院血液内科(成都 610000)
- Keywords:
Bone marrow microenvironment;
Exosome;
Immune cell;
Mesenchymal cell;
Leukaemia
- From:
Practical Oncology Journal
2023;37(6):524-528
- CountryChina
- Language:Chinese
-
Abstract:
The bone marrow microenvironment is a complex network structure composed of non-hematopoietic cells,hemato-poietic stem cells,extracellular matrix,and various cytokines,which is beneficial to maintain normal hematopoietic function in the body.Once bone marrow microenvironment changes,the types and functions of cells in the bone marrow will change,thereby causing the occurrence of leukemia.Leukemia is a malignant clonal disease that is not only related to abnormal proliferation and differentiation of tumor cells,but also closely related to immune dysfunction.Exosomes,immune cells,mesenchymal cells and bone marrow stromal cells(BMSCs)in the bone marrow microenvironment all have immunoregulation effects and can participate in the formation of immune suppression in leukemia,leading to disease progression.Therefore,this article aims to review the mechanism and effects of bone mar-row microenvironment on the pathogenesis of leukemia so as to provide new ideas for leukemia treatment.
