Research status of Agrin involvement in the occurrence and development of malignant tumors
10.11904/j.issn.1002-3070.2023.06.009
- VernacularTitle:Agrin参与恶性肿瘤发生发展的研究现状
- Author:
Shibo ZHAO
1
;
Yongfeng CHEN
;
Huiyi LI
;
Aizhen FU
Author Information
1. 广东医科大学附属医院妇产科(湛江 524000)
- Keywords:
Agrin;
Malignant tumor;
Signaling pathway
- From:
Practical Oncology Journal
2023;37(6):507-512
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor has become the largest disease threatening human health.The global incidence of cancer is in-creasing year by year.At present,the poor quality of life and drug resistance of patients with advanced and recurrent cancer are be-coming increasingly obvious.Reducing the invasion and metastasis of tumor,improving the survival and prognosis of tumor patients,are urgent problems to be solved in tumor treatment.Agrin is a membrane protein associated with synaptic formation,and recent studies have shown that Agrin plays an important role in the occurrence and development of tumors.Agrin is expressed in malignant tumors and immune cells,playing an important regulatory role in tumor angiogenesis,cell proliferation and migration,chemotherapy resist-ance,and neutrophil infiltration.This article summarizes and analyzes the current research status of Agrin,especially its related role and mechanism in the occurrence and development of malignant tumors.
