Research progress on the anticancer activity and mechanism of phytochemical-gamma-tocotrienol
10.11904/j.issn.1002-3070.2023.06.005
- VernacularTitle:植物化学物γ-生育三烯酚抗癌活性与作用机制的研究进展
- Author:
Hao ZHU
1
;
Falin WANG
;
Wenguang SUN
;
Jiaren LIU
Author Information
1. 哈尔滨医科大学附属第四医院检验科(哈尔滨 150001)
- Keywords:
γ-Tocotrienol;
Anti-cancer activity;
Phytochemicals
- From:
Practical Oncology Journal
2023;37(6):485-490
- CountryChina
- Language:Chinese
-
Abstract:
γ-Tocotrienol(γ-T3)is a common phytochemical belonging to a major subclass of natural vitamin E,mainly de-rived from palm oil and rice bran.Compared to saturated tocopherol(TOC),the γ-T3 side chain contains unsaturated bonds and forms isoprene chains.γ-T3 has therapeutic activity for various chronic diseases with broad potential applications,especially in inhib-iting tumor proliferation and invasion.With deeply research,more and more evidence suggests that γ-T3 plays an important role in inhibiting cancer cell migration and metastasis,inducing tumor cell apoptosis,arresting cell cycle and regulating cancer-related sig-naling pathways.Therefore,this article will review the anti-cancer effects and mechanisms of γ-T3.
