Research progress of exosomal miRNA in Clinical diagnosis of lymph node metastasis in thyroid cancer
10.11904/j.issn.1002-3070.2023.05.008
- VernacularTitle:外泌体miRNA在甲状腺癌淋巴结转移临床诊断中的研究进展
- Author:
Wenyuan CAO
1
;
Xiaoting LUO
;
Qian HE
Author Information
1. 山东第一医科大学公共卫生与健康管理学院(济南 250000)
- Keywords:
Thyroid cancer;
Exosomes;
Biomarkers
- From:
Practical Oncology Journal
2023;37(5):434-438
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid cancer(TC)is an inert tumor,with a high proportion of patients undergoing lymph node metastasis(LNM),and a high recurrence rate after metastasis,resulting in a poor clinical prognosis.The key to solving this problem is to find non-invasive biomarkers with high specificity.Extracellular vesicles play a crucial role in intercellular communication and epigenetic regulation by transporting genetic material.TC tumor cells can transfer genetic information to the tumor microenvironment through miRNA in exosomes,changing the surrounding microenvironment into an environment suitable for tumor growth,thereby promoting pro-liferation and migration of TC.This article will review the role and application prospects of extracellular miRNAs in the early diagnosis of TC metastasis in recent years,to provide a reference for exploring biomarkers of TC.
