Research progress of the endoplasmic reticulum-mitochondrial interactions in post-stroke cognitive impair-ment

VernacularTitle:内质网-线粒体互作在卒中后认知障碍中的研究进展
Author: Lulu CHEN ¹ ; Meng LUO ; Kaiqi SU ; Jing GAO ; Xiaodong FENG
Author Information

1. 河南中医药大学(郑州 450046)
Keywords: stroke; cognitive impairment; endoplasmic reticulum mitochondrial interactions; mito-chondrial dynamics; autophagy; review
From: The Journal of Practical Medicine 2024;40(7):1023-1028
CountryChina
Language:Chinese
Abstract: Post-stroke cognitive impairment(PSCI),refers to a range of clinical syndromes of cognitive impairment caused by stroke.Although its specific pathogenesis is still unclear,many studies have confirmed that endoplasmic reticulum-mitochondria interaction has become a key hub for intracellular signal transduction and substance metabolism,and its regulation of various biological processes,such as Ca2+ balance,lipid metabolism,mitochondrial dynamics,autophagy,and neuroinflammation,is closely related to the development of PSCI.There-fore,in this paper,we will review the various functions of endoplasmic reticulum-mitochondrial interactions and explore their specific roles in PSCI,in order to discover new therapeutic targets and provide new theoretical basis and references for the development of PSCI-targeted drugs in the future.