Values of renal resistance index combined with blood and urinary biomarkers in early prediction of contrast-induced acute kidney injury after interventional surgery
10.3969/j.issn.1006-5725.2024.07.023
- VernacularTitle:肾阻力指数联合血液和尿液生物标志物早期预测介入术后造影剂诱导的急性肾损伤的价值
- Author:
Ting HUANG
1
;
Rongcheng XIE
;
Yuting WANG
;
Xiaoming LIN
;
Jiefei MA
Author Information
1. 复旦大学附属中山医院(厦门)危急重症科(福建厦门 361006)
- Keywords:
contrast-induced acute kidney injury;
CysC;
Urine NAG;
renal resistance index;
blood β2-microglobulin
- From:
The Journal of Practical Medicine
2024;40(7):1011-1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the values of renal resistance index(RRI),cystatin C(CysC),blood β2-microglobulin(β2-MG)and urinary N-acetyl-β-glucosamine glycosidase(NAG)in early prediction of contrast-induced acute kidney injury(CI-AKI).Methods A retrospective cohort analysis on 207 postoperative patients after intervention therapy was conducted.The patients were divided into AKI group(18 patients)and non-AKI group(189 patients)based on whether CI-AKI occurred.General and clinical data were collected and compared.Accord-ing to the time of diagnosis of AKI(D0 on the day of surgery or D1 on the first day after surgery),the AKI group was divided into AKI(D0)group and AKI(D1)group.Indicators RRI,CysC,and blood β2-MG,serum creatinine(sCr),and urinary NAG were compared between the two groups.The risk factors of CI-AKI were explored using logistic regression and linear regression.Results In the AKI group,males,preoperative sCr,acute physiological and chronic health(APACHⅡ)score and sequential organ failure(SOFA)score,surgical duratrion,sCr,CysC,blood β2-MG,urinary NAG on the day of surgery and the first day after surgery,and RRI were higher than those in the non-AKI group;Higher APACHEⅡ and SOFA scores and higher CysC level on D1 were independent risk factors for the occurrence of CI-AKI(P<0.05).Levels of CysC and urinay NAG on D0 were higher in the AKI(D0)group than in the AKI(D1)group(P<0.05).RRI,urinary NAG and blood β2-MG were not independent risk factors for CI-AKI.Conclusions CysC and urinary NAG are powerful predictors for the prediction of CI-AKI,and RRI and blood β2-MG cannot predict the occurrence of CI-AKI early.
