The predictive value of 18F-FDG PET/CT metabolic heterogeneity parameters combined with clinical features for the prognosis of esophageal squamous cell carcinoma before definitive radiochemotherapy
10.3969/j.issn.1006-5725.2024.07.015
- VernacularTitle:根治性放化疗前18F-FDG PET/CT代谢异质性参数结合临床特征对食管鳞状细胞癌预后的预测价值
- Author:
Xiya MA
1
;
Hu JI
;
Zehua ZHU
;
Bo PAN
;
Qiang XIE
;
Xiaobo YAO
Author Information
1. 蚌埠医学院研究生院(安徽蚌埠 233000)
- Keywords:
esophageal squamous cell carcinoma;
intra-tumor metabolic heterogeneity;
intensity-modu-lated radiotherapy;
PET/CT;
prognosis
- From:
The Journal of Practical Medicine
2024;40(7):966-971
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to explore the prognostic value of 18F-FDG PET/CT Metabolic and Heterogeneity Parameters Combined with Clinical Features Before Definitive Chemoradiotherapy(D-CRT)in predicting the prognosis of esophageal squamous cell carcinoma(ESCC)Patients.Methods A retrospective analysis was conducted on clinical data from 106 patients with ESCC who received D-CRT at the first affiliated Hospital of University of Science and Technology of China between January 2017 and December 2021.All patients underwent 18F-FDG PET/CT examination before the treatment.The primary tumor′s metabolic and heterogeneity parameters were obtained through data processing.All patients were followed up for overall survival.The Kaplan-Meier method and Cox proportional hazards models were used to analyze the association between clinical features,tumor metabo-lism and heterogeneity parameters and patient prognosis.Results The 1-and 1.5-year overall survival rates of all patients were 77.4%and 51.9%.The median survival time was 20 months.Univariate analysis showed that N stage,M stage,metabolic tumor volume,total lesion glycolysis,heterogeneity index-2(HI-2),and coefficient of variation with a threshold of 40%maximum standard uptake value(CV40%)were correlated with the prognosis of ESCC(all P<0.05).Multivariate analysis showed that N stage and CV40%were independent predictors of prognosis in patients with ESCC(P = 0.039 and P<0.001,respectively).Conclusion N stage and tumor metabolic heterogeneity parameter CV40%,which offering a degree of predictive value,are closely related to the prognosis of patients with ESCC treated with D-CRT.
