Research progress of exosomes in distant metastasis and drug resistance of gastric cancer
10.3969/j.issn.1006-5725.2024.06.024
- VernacularTitle:外泌体在胃癌远处转移和耐药性中的研究进展
- Author:
Shu CHEN
1
;
Jinglei ZHANG
;
Kang RONG
;
Nan ZHANG
;
Weiyi SUN
Author Information
1. 河南中医药大学(郑州 450046)
- Keywords:
gastric cancer;
exosomes;
metastasis;
drug resistance;
chemotherapy
- From:
The Journal of Practical Medicine
2024;40(6):870-876
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer(GC)is one of the most common tumors and the fourth leading cause of cancer-related death worldwide.Due to the lack of specific signs in early GC,most cases are diagnosed at an advanced stage,often accompanied by infiltration and distant metastasis.Although chemotherapy is the most commonly used treatment for gastric cancer,due to the emergence of drug resistance,many patients will still relapse after chemo-therapy,resulting in poor prognosis.Exosome(EXOs)in the Tumor micro environment(TME)can participate in intercellular communication and play an important role in GC distant metastasis and drug resistance.At present,the detailed mechanism of GC distant metastasis and drug resistance is still unclear.Identifying the exosome-induced mechanism involved in GC distant metastasis and drug resistance can help us find more reliable treatment methods for GC metastasis and drug resistance.This article reviews the mechanism of exosome in GC distant metastasis and drug resistance,in order to provide help for the diagnosis,treatment and research of GC.
