Research progress in the treatment of AMPK regulating lipid accumulation in the treatment of nonalcoholic fatty liver disease
10.3969/j.issn.1006-5725.2024.06.022
- VernacularTitle:AMP依赖的蛋白激酶调节脂质积累治疗非酒精性脂肪肝病的治疗研究进展
- Author:
Pengshuai SUN
1
;
Feng ZHU
;
Lihong ZHENG
;
Haiqiang WANG
Author Information
1. 黑龙江中医药大学第一临床医学院(哈尔滨 150040)
- Keywords:
non-alcoholic fatty liver disease;
AMPK;
lipid metabolism;
clinical treatment
- From:
The Journal of Practical Medicine
2024;40(6):862-866
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease and has posed significant challenges to global public health and medical care.Due to the unclear pathogenesis of NAFLD,lipid accumulation plays a key role in its development.AMPK,as a crucial molecule in lipid metabolism regulation,can improve lipid accumulation caused by NAFLD.This article describes the specific mechanisms of AMPK-related molecules in improving lipid accumulation and treating NAFLD,and lists the current experimental and therapeutic drugs related to AMPK.The potential of AMPK-related drugs in improving lipid accumulation and treating NAFLD is demonstrated,providing ideas and references for future research on AMPK-related drugs for treating NAFLD.
