Correlation between IL-17 gene polymorphism and type 2 diabetes mellitus in Han population in southeast Shanxi Province
10.3969/j.issn.1006-5725.2024.05.018
- VernacularTitle:白细胞介素-17基因多态性与山西东南地区汉族人群2型糖尿病的相关性
- Author:
Yan LI
1
,
2
;
Qi WANG
;
Lu ZHENG
;
Lihui FENG
;
Li MA
;
Jian WEI
;
Liangshu LIU
Author Information
1. 长治医学院附属和平医院内分泌科(山西长治 046000)
2. 长治医学院内分泌代谢性疾病研究所(山西长治 046000)
- Keywords:
type 2 diabetes mellitus;
interleukin-17;
genetic polymorphism
- From:
The Journal of Practical Medicine
2024;40(5):695-701
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the correlation between single-nucleotide polymorphisms of IL-17 with type 2 diabetes in Han population in southeastern Shanxi Provincein.Methods The basic information and related clinical data of the subjects were collected of normal healthy controls and T2DM.Whole blood DNA was extracted,and IL-17 polymorphisms(rs2275913,rs3819024,rs4711998 and rs8193036)were analyzed by using a polymerase chain reaction-high temperature ligase reaction.Results There was no significant difference in the genotype and allele frequency distribution of the four SNP loci of IL-17 gene between the two groups(P>0.05).IL-17 polymorphism was not linked with T2DM in multiple genetic models after controlling for age,BMI,WC,and dyslipidemia(P>0.05).Further analysis showed that the levels of AA genotype was substantially lower of FPG and HOMA-IR levels when compared with the AG and GG genotypes,and the differences among the three groups were statistically significant(P<0.05).However,BMI,FINS,HbA1c and HOMA-βwas no statistical significance among the three groups(P>0.05).Besides,WC and HOMA-IR of AA genotype(rs3819024)were notable higher than those of GG genotype in T2DM group(P<0.05).Conclusions The IL-17 gene polymorphisms rs2275913,rs3819024,rs4711998,and rs8193036 in the Han population of southeast Shanxi Province may not be associated with T2DM.In this region Han T2DM patients,AA genotype at rs2275913 of the IL-17 gene is associ-ated to FPG and HOMA-IR,while GG genotype at rs3819024 is related to WC and HOMA-IR,which could be the potential genotype of IL-17 impacting glucose metabolism.
