Association of anti-neutrophil cytoplasmic antibodies with the disease activity in patients with systemic lupus erythematosus
10.3969/j.issn.1006-5725.2024.05.012
- VernacularTitle:抗中性粒细胞胞浆抗体与系统性红斑狼疮患者疾病活动度的相关性
- Author:
Xiaoyi SONG
1
,
2
;
Chengjie XU
;
Hangfeng ZHANG
;
Jiajia WANG
Author Information
1. 四川省医学科学院·四川省人民医院(电子科技大学附属医院)临床医学检验中心(成都 610072)
2. 电子科技大学医学院(成都 610054)
- Keywords:
anti-neutrophil cytoplasmic antibodies;
systemic lupus erythematosus;
IL-6;
peri-nuclear anti-neutrophil cytoplasmic antibody;
systemic lupus erythematosus disease activity index
- From:
The Journal of Practical Medicine
2024;40(5):658-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of ANCA in the disease activity of patients with SLE.Methods A total of 1 025 SLE patients were recruited and were divided into inactive and active groups according to SLEDAI score.Demographic characteristics,clinical symptoms,autoantibodies,routine laboratory tests and renal pathology were also recorded and compared between the two groups.Results All patients were divided into inactive group(n = 750)and active group(n = 250).The occurrence of renal,pulmonary,cutaneous,arthritis manifestations were significantly higher than those of the inactive group(all P<0.05).All patients were tested for ANCA,and the most common pattern being perinuclear or p-ANCA,the percentage of p-ANCA seroposi-tive increased greatly with the increased disease activity(P<0.05).The autoantibodies were further analyzed between the two groups,25 patients had reactivity to MPO,but no patient had reactivity to PR3.Also,there were significant differences in anti-dsDNA antibody,anti-nucleosome antibody between the two groups(P<0.05).In the active group,patients with p-ANCA seropositive exhibited higher serum beta-2-microglobulin(β2-MG),titers of anti-dsDNA antibody,SLEDAI scores,lower albumin,C3,and C4 levels(P<0.05).Meanwhile,p-ANCA was associated with IL-6,which increased significantly with the increase of SLEDAI score.In addition,patients with p-ANCA seropositive had more occurrence of lupus nephritis,but it had no association with the renal pathology.Conclusion The appearance of p-ANCA in SLE patients indicated more severe disease activity status.
