The causal relationship between chemokine CCL2 and lung cancer:a two-sample Mendelian randomization study

VernacularTitle:趋化因子CCL2与肺癌的因果关系:两样本孟德尔随机化研究
Author: Zishen LIU ¹ ; Yingying ZHENG ; Mengqi YUAN ; Ganlin ZHANG ; Guowang YANG
Author Information

1. 首都医科大学附属北京中医医院北京 100010
Keywords: Mendelian randomization; monocyte chemokine; lung cancer; causality
From: The Journal of Practical Medicine 2024;40(4):532-536
CountryChina
Language:Chinese
Abstract: Objective To investigate whether chemokine CCL2(also known as monocyte chemotactic protein 1 or MCP-1)has a causal relationship with lung cancer.Methods Genetic data of chemokine CCL2 and different pathological subtypes of lung cancer were extracted from genome-wide association studies(GWAS),and inverse-variance weighted(IVW)analysis was used as main analysis,while weighted median,simple model,MR-Egger regression,and weighted model were chosen as supplementary analyses.Sensitivity analyses were performed to verify the reliability of the data.Results The result of IVW analysis on chemokine CCL2 to lung adenocarcinoma was OR = 1.065,95%CI(0.919～1.234),P = 0.401.The result of IVW analysis on chemokine CCL2 to squamous cell lung carcinoma was OR = 1.059,95%CI(0.931～1.205),P = 0.381.The result of IVW analysis on chemokine CCL2 to small cell lung carcinoma was OR = 0.959,95%CI(0.760～1.208),P = 0.720.Conclusions There is no direct causal relationship between chemokine CCL2 and lung cancer.