Expression of SLC35A2 and PFDN2 in breast cancer and its relationship with clinical observables and prog-nosis
10.3969/j.issn.1006-5725.2024.04.010
- VernacularTitle:SLC35A2、前叶黄素亚基2在乳腺癌中的表达及其与临床观察指标和预后的关系
- Author:
Zixu SONG
1
;
Guangzheng ZHU
;
Chenxu GUO
;
Jiaqi WU
;
Ligong ZHANG
;
Jun QIAN
Author Information
1. 蚌埠医科大学第一附属医院肿瘤外科 安徽蚌埠 233000
- Keywords:
breast cancer;
SLC35A2;
PFDN2;
prognosis
- From:
The Journal of Practical Medicine
2024;40(4):496-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of SLC35A2 and PFDN2 in breast cancer and their relationship with clinical indicators and prognosis.Methods TCGA database and TIMER 2.0 database were used to analyze the differences of SLC35A2 and PFDN2 expression in breast cancer tissues and paracancerous tissues;K-M database was used to create the survival curves of patients in the high and low expression groups of the two.qRT-PCR and immunohistochemistry were used to detect the expression of SLC35A2 and PFDN2 in the cancerous and paracancerous tissues,and the expression differences,the relationship between their expression levels and the clinical observation indexes were statistically analyzed,and the independent prognostic factors of breast cancer were screened out;K-M survival analysis was used to compare the prognostic differences between the groups and create the survival curves.Results The expression levels of SLC35A2 and PFDN2 in breast cancer tissues were significantly higher than those in paracancerous tissues according to the results of biopsy,qRT-PCR and immuno-histochemistry,and the expression levels of SLC35A2 were significantly correlated with lymph node metastasis,while the expression of PFDN2 was significantly correlated with the diameter of the tumor and the metastasis of lymph nodes,and the expression of SLC35A2 and PFDN2 was an independent prognostic factor for breast cancer.patients had the worst prognosis.Conclusion The expression of SLC35A2 and PFDN2 in breast cancer tissues was closely related to clinical indicators and prognosis of breast cancer,and could be used as a potential target for breast cancer treatment.
