Research progress on antidepressant pharmacological effects and mechanisms of Bupleuri Radix-Paeoniae Radix Alba herb-pair
10.3969/j.issn.1006-5725.2024.04.002
- VernacularTitle:柴胡-白芍配伍抗抑郁药理作用机制研究进展
- Author:
Kanglin CAI
1
,
2
;
Jinkai ZHANG
;
Liangdi RAN
;
Dajun HU
;
Zhitao FENG
;
Huilian HUANG
Author Information
1. 三峡大学附属第二人民医院/宜昌市第二人民医院 湖北宜昌 443008
2. 三峡大学 基础医学院, 湖北宜昌 443002
- Keywords:
Bupleuri Radix-Paeoniae Radix Alba;
herb-pair;
depression;
inflammatory response,oxidative stress
- From:
The Journal of Practical Medicine
2024;40(4):447-452
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a frequently-seen mental disorder that profoundly affects the survival and quality of life of individuals.Present clinical medicine therapies for depression are not fully efficacious and novel therapeutic agents and targets remain necessary.Bupleuri Radix-Paeoniae Radix(BR-PRA),an essential and crucial compo-nent of traditional antidepressant compound,possesses the beneficial effect of lowering toxicity and amplifying the antidepressant effect when utilized in combination.The underlying mechanisms of these synergistic effects may involve the suppression of inflammation and oxidative stress,the regulation of monoamine neurotransmitters,brain-derived neurotrophic factors,the modulation of the hypothalamus-pituitary-adrenal axis,and the metabolism of various amino acids and energy.This article summarizes the synergistic effects and antidepressant pharmacological effects of BR-PRA herb-pair,thereby providing valuable insights into the potential advantages of this combination and its potential mechanisms of antidepressant action.
