Effects of Diosmine on semen quality and sex hormone concentration in patients with spermatovenous liga-tion
10.3969/j.issn.1006-5725.2024.03.019
- VernacularTitle:地奥司明对精索静脉高位结扎术后患者精液质量及性激素浓度的影响
- Author:
Kaiqiang WANG
1
,
2
;
Zhi CAO
;
Wei WANG
;
Chenglin YANG
;
Yue YANG
;
Huifen ZHANG
;
Xaioming ZHANG
Author Information
1. 广州中医药大学研究生院(广州 510405)
2. 中国人民解放军南部战区总医院泌尿外科(广州 510010)
- Keywords:
varicocele;
semen quality;
laparoscopic varicocelectomy;
diosmine
- From:
The Journal of Practical Medicine
2024;40(3):389-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of diosmine on semen quality and sex hormone concentra-tion in patients with spermatovenous ligation.Methods Clinical data were retrospectively collected from January 2019 to January 2022 on patients with varicocele admitted to Department of Urology,General Hospital of Southern Theater Command,divided into a control group and a study group based on whether they had a history of Diosmine use after surgery.Clinical data from both groups were matched using propensity score matching.Sperm quality and sex hormone tests were then compared before surgery,three months after surgery and six months after surgery.Results There were 73 in the control group and 73 in the study group.Both groups were balanced in terms of age,BMI,seminal fluid volume and testosterone(P＞0.05).Sperm motility,forward motility and testosterone were all increased 3 and 6 months after surgery,and sperm malformations,sperm DNA fragment index,follicle stimulating hormone and luteinizing hormone were all reduced significantly(P＜0.05).The results were also better than those in the control group for total sperm motility,forward motility,testosterone,sperm DNA fragment index,follicle stimulating hormone and luteinizing hormone(P＜0.05).Conclusions Diosmine can help to restore semen quality and improve sex hormone concentration in patients with varicocele after Laparoscopic varicocelectomy.
