Association of high triglyceride glucose index with increased mortality in peritoneal dialysis:A cohort study
10.3969/j.issn.1006-5725.2024.03.016
- VernacularTitle:高甘油三酯葡萄糖乘积指数与腹膜透析患者病死率增加相关的队列研究
- Author:
Shan YANG
1
,
2
;
Hongying LI
;
Jingxuan ZHOU
;
Yaode CHEN
;
Yaqin LI
;
Ziqi GU
;
Hongxin NIU
Author Information
1. 南方医科大学珠江医院 全科医学科 (广州 510220)
2. 广州市海珠区龙凤街社区卫生服务中心(广州 510250)
- Keywords:
triglyceride glucose index;
peritoneal dialysis;
mortality
- From:
The Journal of Practical Medicine
2024;40(3):371-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study is to investigate whether there is a correlation between a high TyG index(serum triglyceride glucose index)and higher mortality rates among patients undergoing peritoneal dialysis(PD).Methods This study utilized a single-center retrospective cohort as the basis for its methods..From January 1,2007 to December 31,2015,a total of 519 PD patients kept under observation until December 31,2018.There searchers employed the Kaplan-Meier method and Cox proportional hazards modelsto examine the cor-relation between TyG index levels and mortality.Results Over a period of 40.5 months,104(20.0%)individuals with Parkinson's disease passed away,with 55(52.9%)of these deaths attributed to cardiovascular disease(CVD).The serum median TyG index at baseline was 8.44(6.48,11.94).Through Cox regression analysis subject to the adjustments of such parameters as gender,age,body mass index(BMI),presence of cardiovascular disease,hypertension,diabetes mellitus,hemoglobin,serum albumin,serum Ferritin,total cholesterol,renal residual function(RRF),An increased risk of all-cause mortality(HR = 2.22,95%CI:1.43～3.44,P＜0.001)and CVD mortality(HR = 2.50,95%CI:1.34～4.65,P = 0.004)was observed with a higher baseline TyG index(8.44).A comparable impact was observed in the correlation between the average TyG index over time(TA-TyG index)and both all-cause mortality and CVD mortality.(HR = 1.90,95%CI:1.25～2.90,P = 0.003;HR = 2.05,95%CI:1.14～3.70,P = 0.017,respectively).Conclusion PD patients with a higher serum TyG index have a greater risk of all-cause mortality and mortality related to cardiovascular disease.
