Effects of LPE combined with DPMAS on liver function and inflammatory cytokines in patients with acute-chronic liver failure
10.3969/j.issn.1006-5725.2024.03.012
- VernacularTitle:低置换量血浆置换术联合双重血浆分子吸附术治疗慢加急性肝衰竭患者短期预后的结果
- Author:
Bo ZOU
1
;
Longchuan ZHU
;
Dakai GAN
;
Xinyao ZHANG
;
Xuebing YAO
Author Information
1. 南昌大学第二附属医院 (南昌 330000)
- Keywords:
lymphoplasmapheresis;
dual plasma molecular adsorption system;
acute-on-chronic liver failure;
liver function;
inflammatory cytokine
- From:
The Journal of Practical Medicine
2024;40(3):348-352,359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of low replacement plasma exchange(LPE)combined with double plasma molecular adsorption(DPMAS)in the treatment of patients with chronic acute liver failure(ACLF)and its influence on liver function,inflammatory cytokines and short-term prognosis.Methods One hundred patients with ACLF were randomly divided into the observation group and the control group by envelope method,with 50 cases in each group.On basis of routine symptomatic treatments(liver protection,removing jaundice,reducing enzymes,anti-viruses,bleeding prevention),the control group and the observation group were treated with plasma exchange(PE)and LPE plus DPMAS,respectively.The liver function,coagulation function,the levels of inflammatory cytokines,incidence of adverse reactions,and 90-day survival rate were compared between the two groups after treatment.Results After treatment,the liver function and coagulation function in the observation group were significantly improved(P＜0.05)and the levels of inflammatory cytokines were significantly lowered than those in the control group(P＜0.05).There was no statistically significant difference in the 90-day survival rate and the total incidence of adverse reactions between the groups(P＞0.05).Conclusion LPE combined with DPMAS can effectively improve liver function and coagulation function,and reduce levels of inflammatory cyto-kines in ACLF patients,with high safety.
