Application and prospects of ctDNA detection in HPV associated cervical cancer
10.3969/j.issn.1006-5725.2024.02.001
- VernacularTitle:循环肿瘤DNA检测在人乳头瘤病毒相关性宫颈癌中的应用与展望
- Author:
Baoni JIANG
1
;
Meiqin ZHANG
;
Lu YANG
;
Zhiyuan CHEN
;
Na'na HAN
Author Information
1. 南方医科大学珠江医院妇产医学中心 (广州 510280)
- Keywords:
HPV-ctDNA;
HPV;
cervical cancer;
gynecologic malignancy;
vulva cancer;
vagina cancer
- From:
The Journal of Practical Medicine
2024;40(2):129-132
- CountryChina
- Language:Chinese
-
Abstract:
Circulating tumor DNA(ctDNA)is a kind of cell-free DNA derived from tumors,which carries comprehensive tumor genetic information;Recent studies have found that ctDNA detection can play a role in the early diagnosis,targeted therapy,and prediction of recurrence in tumors.Human papillomavirus(HPV)-associated gynecological malignancies include most cervical cancer,some vulvar cancer,and vaginal cancer.High-risk HPV long-term infection and integration with cell genome are important causes of these cancers.Studies found that the use of ctDNA detection technology to dynamically monitor changes in HPV-ctDNA can provide valuable information for the clinical management and prognosis of these cancers.Thus,HPV-ctDNA is expected to become an biomarker for HPV-associated tumors.
