Clinical efficacy of CalliSpheres drug-loaded microspheres versus blank microspheres in the treatment of advanced non-small cell lung cancer by transarterial chemoembolization
10.3969/j.issn.1006-5725.2024.01.006
- VernacularTitle:CalliSpheres药物洗脱微球和空白微球经动脉化疗栓塞术治疗中晚期非小细胞肺癌的比较
- Author:
Ruiwen CHENG
1
;
Ruobing HAO
;
Ping LI
;
Kun ZHANG
;
Liping DENG
;
Yaheng CAO
;
Lin SU
;
Hongrong SHEN
Author Information
1. 湖南中医药大学第一附属医院血管肿瘤介入科 (长沙 410021)
- Keywords:
non-small cell lung cancer;
drug-carrying microspheres;
arterial chemoembolization
- From:
The Journal of Practical Medicine
2024;40(1):32-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and compare the clinical efficacy of CalliSpheres drug-eluting micro-spheres and blank microspheres in the treatment of advanced non-small cell lung cancer by bronchial arterial chemoembolization.Methods Fifty patients with advanced non-small cell lung cancer who had failed or relapsed after radiotherapy,chemotherapy,targeting and immunotherapy were collected and treated with super-selective bronchial artery chemoembolization.A retrospective analysis was conducted to compare the tumor response rate and survival between CalliSpheres drug-eluting and blank microspheres.Results The PR,ORR and DCR in the drug-eluted microsphere group were higher than those in the blank microsphere group,and there was a statistical difference in DCR between the two groups 1 month after surgery(χ2 = 4.08,P = 0.04).PD in the drug-eluted microsphere group was lower than that in the blank microsphere group.The CEA,CYF and SCC in the drug-eluted microsphere group after surgery were lower than those in the blank microsphere group,and the CEA,CYF and SCC in the two groups after surgery were lower than those before surgery,and there were statistical differences in CEA and CYF 1 month after surgery between the two groups.The PFS and OS in drug-eluted microsphere group were higher than those in blank microsphere group.Conclusion CalliSpheres drug-eluting microspheres could improve the effective rate of tumor treatment and prolong the survival time more effectively than the blank micro-spheres via arterial chemoembolization,providing reliable clinical practice basis for the treatment of advanced non-small cell lung cancer.
