The mechanism of lipid metabolism disorders promoting progression of lung cancer based on the oxLDL/LOX-1 signaling pathway
10.3969/j.issn.1006-5725.2024.01.004
- VernacularTitle:基于ox-LDL/LOX-1信号通路探讨脂质代谢紊乱促进肺癌进展中的机制
- Author:
Yang WU
1
;
Jian YAO
;
Jinliang CHEN
Author Information
1. 南通市第一人民医院感染科 (江苏南通 226001)
- Keywords:
oxidized low density lipoprotein;
human lectin-like oxidized low density lipoprotein receptor 1;
lung cancer;
lipid metabolism
- From:
The Journal of Practical Medicine
2024;40(1):19-24,31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of lipid metabolism disorder promoting the progress of lung cancer based on the oxidized low density lipoprotein(ox-LDL)/human lectin-like oxidized low density lipopro-tein receptor 1(LOX-1)signaling pathway.Methods Eighty-one identified lung adenocarcinoma tissues with paired adjacent non-cancerous tissues(at least 5 cm away from the tumor)were collected from our hospital,and the expression of LOX-1 was detected by immunohistochemistry.LOX-1 was overexpressed in lung adenocarcinoma cell lines(A549 and H1299 cells).Cell invasion ability was measured by Transwell.Cells were treated with different concentrations of oxLDL,and cellular LOX-1 expression was investigated.Results LOX-1 staining in the tumor was significantly stronger than that in the non-cancerous tissue samples(99.4 vs.16.2 for median H score,P<0.001).High LOX-1 expression was significantly correlated with low survival(P<0.001).As compared with the patients without lymph node metastasis,those with lymph node metastasis had higher LOX-1 level(83.2 vs.121.1 for median H score,P<0.01).Overexpression of LOX-1 in lung cancer cells significantly promoted the number of invasive and metastatic cells(P<0.01).In addition,LOX-1 was an essential functional target for oxLDL-induced metastasis of lung cancer cells.Itatinib inhibited the metastasis of LOX-1 overexpressed A549 in vitro.Conclusions With an increase in oxLDL level,the expression of LOX-1 increases.Up-regulation of LOX-1 promotes metastasis of lung cancer,and its mechanism may be related to activation of the JAK1/STAT6 signaling pathway.
