PIRO concept is used to analyze the characteristics of different types of hepatitis B-related acute-on-chronic liver failure
10.3969/j.issn.1006-5725.2023.24.026
- VernacularTitle:不同分型乙肝相关慢加急性肝衰竭以PIRO概念进行特点分析
- Author:
Chunyan LI
1
,
2
;
Huaqian XU
;
Shanhong TANG
Author Information
1. 中国人民解放军西部战区总医院消化内科(成都 610083)
2. 成都中医药大学医学与生命科学学院(成都 610072)
- Keywords:
acute-on-chronic liver failure;
hepatitis B;
PIRO concept;
clinical characteristics
- From:
The Journal of Practical Medicine
2023;39(24):3297-3300
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure(ACLF)is generally accepted as a clinical syndrome characterized by an acute hepatic insult and rapid deterioration of liver function in patients with pre-existing chronic liver disease in combination with multi-organ failure with high short-term mortality.Because of the differences in etiology and inducement,there are different definitions and diagnostic criteria of ACLF in the East and West.Attempting to cover all ACLF diagnosed,WGO defined ACLF into three categories in 2014:patients with CLD but no cirrhosis(type A),compensated cirrhosis(type B),and decompensated cirrhosis(type C).However,different types of ACLF have different pathophysiology,which leads to obvious differences in predisposition,injury,response,organ failure and mortality among different types of ACLF.The concept of PIRO,which is similar to that used in determining outcomes of sepsis,is contribute to comprehensively understand different types of HBV-ACLF,improve management.Therefore,it is of great significance to improve the survival rate of ACLF.
