Characteristics of opportunistic infections in HIV-infected individuals with suboptimal immune reconstruc-tion in Guangxi
10.3969/j.issn.1006-5725.2023.23.010
- VernacularTitle:广西免疫重建不良的人类免疫缺陷病毒感染者发生机会性感染的特点
- Author:
Lei JI
1
;
Tiantian LI
;
Jianlin WU
;
Xianli XU
;
Chunlan ZHANG
;
Xiaojie LAO
;
Xinyin MEI
;
Yangni LU
;
Maowei CHEN
Author Information
1. 广西医科大学武鸣临床医学院(南宁 530199)
- Keywords:
HIV;
opportunistic infections;
suboptimal immune reconstruction;
antiretroviral therapy
- From:
The Journal of Practical Medicine
2023;39(23):3082-3086
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of opportunistic infections(OIs)in HIV-infected indi-viduals with suboptimal immune reconstitution after ART treatment so as to provide a reference for preventing and managing HIV infections.Methods The clinical data including opportunistic infections specifically were acquired from 112 HIV-infected individuals with suboptimal immune reconstitution from the outpatient department of Wuming Hospital,Guangxi Medical University.The impact of baseline CD4+T lymphocyte counts on the incidence,type,and mixed infection rates of the opportunistic infections were analyzed.Results The opportunistic infection rate among the 112 HIV-infected individuals with suboptimal immune reconstitution was 42.86%,among which fungal infections were the most commonly seen.The opportunistic infection rate of the patients with a baseline of CD4+T lymphocyte counts≤50/μL was significantly higher than that of the patients with a baseline of CD4+T lymphocyte counts>50/μL,and there was no significant difference in the type of opportunistic infections as well as the rate of mixed infections.Conclusion HIV-infected people with suboptimal immune reconstitution in Guangxi are susceptible to HIV OIs.Among them,the group with a baseline CD4+ T lymphocyte counts≤50/μL has a higher rate of OIs,mainly fungal infections.
