NIR-controlled transdermal delivery of atenolol based on polyethyleneimine-modified MoS2 nanoparticles

VernacularTitle:聚乙烯亚胺修饰化二硫化钼光控纳米粒在阿替洛尔经皮递药中的应用
Author: Yijian CUI ¹ ; Kai ZHANG ; Tianqi QIAO ; Xiaochang LIU
Author Information

1. 沈阳医学院基础医学院,辽宁沈阳 110034
Keywords: MoS2 nanoparticles; transdermal drug delivery system; controlled release system; near infrared laser irradiation; polyethyleneimine
From: Journal of Shenyang Medical College 2024;26(1):11-17
CountryChina
Language:Chinese
Abstract: Objective:Using atenolol as a model drug,the aim of this study was to develop a sustained and controlled transdermal drug delivery system(TDDS)based on polyethyleneimine-modified MoS2 nanoparticles(PEI-MoS2 NPs)that were responsive to near infrared(NIR)laser irradiation.Methods:The three-dimensional flower-like PEI-MoS2 NPs were successfully synthesized and further characterized by attenuated total reflection Fourier transform infrared spectroscopy,X-ray diffraction measurements,scanning electron microscopy,and transmission electron microscopy.The controlled release capacity of PEI-MoS2 NPs was examined using in vitro drug release and skin penetration experiments.Results:The PEI-MoS2 NPs exhibited a drug loading efficiency of 53.86% and high photothermal conversion ability.Moreover,the release of atenolol was enhanced by NIR stimulation with an enhancement ratio of 1.56.Conclusion:NIR-controlled PEI-MoS2 NPs was essential for the control and sustained release of drugs in TDDS.