Mevalonic acid reverses the antitumor effects of fluvastatin sodium on tongue squamous cell carcinoma cells
10.3969/j.issn.1001-3733.2024.02.013
- VernacularTitle:甲羟戊酸逆转氟伐他汀钠对舌鳞癌细胞的抑制作用
- Author:
Yemei QIAN
1
;
Weihong WANG
;
Lin ZENG
;
Jingyi LI
;
Wenguang TANG
;
Zhe ZHANG
Author Information
1. 650106,昆明医科大学附属口腔医院口腔颌面外科,云南省口腔医学重点实验室
- Keywords:
Tongue squamous cell carcinoma;
Fluvastatin sodium;
Mevalonate acid
- From:
Journal of Practical Stomatology
2024;40(2):227-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate mevalonic acid(MEV)on reversing the antitumor effects of fluvastatin sodium(FS)on tongue squamous cell carcinoma(TSCC)cells.Methods:TSCC HSC-4 cells were treated with different concentrations of FS and MEV re-spectively or in combination.Cell counting kit-8,flow cytometry,wound healing,immunofluorescence and western blotting assays were conducted to examine cell proliferation,apoptosis and migration capacities,as well as the expression levels of Ras homolog family member A(RHOA),tissue factor(TF)and B-cell lymphoma-2-associated X(BAX)proteins,respectively.Results:FS inhibited HSC-4 cell proliferation and migration,decreased the expression of RHOA and TF,and increased BAX expression.MEV reversed the above antitumor effects of FS and promoted intracellular RHOA and TF expression.Conclusion:MEV reverses the antitumor effects of FS on HSC-4 cells in vitro.
