A Comparison of Two Brands of Clopidogrel in Patients With Drug-Eluting Stent Implantation.
10.4070/kcj.2012.42.7.458
- Author:
Yae Min PARK
1
;
Taehoon AHN
;
Kyounghoon LEE
;
Kwen Chul SHIN
;
Eul Sik JUNG
;
Dong Su SHIN
;
Myeong Gun KIM
;
Woong Chol KANG
;
Seung Hwan HAN
;
In Suck CHOI
;
Eak Kyun SHIN
Author Information
1. Cardiology Division, Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. encore@gilhospital.com
- Publication Type:Original Article
- Keywords:
Generic drug;
Treatment outcome clopidogrel;
Stent thrombosis
- MeSH:
Blood Platelets;
Coronary Artery Disease;
Drug-Eluting Stents;
Follow-Up Studies;
Glycosaminoglycans;
Humans;
Incidence;
Myocardial Infarction;
Retrospective Studies;
Stents;
Stroke;
Tablets;
Thrombosis;
Ticlopidine
- From:Korean Circulation Journal
2012;42(7):458-463
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Although generic clopidogrel is widely used, clinical efficacy and safety between generic and original clopidogrel had not been well evaluated. The aim of this study was to evaluate the clinical outcomes of 2 oral formulations of clopidogrel 75 mg tablets in patients with coronary artery disease (CAD) undergoing drug-eluting stent (DES) implantation. SUBJECTS AND METHODS: Between July 2006 and February 2009, 428 patients that underwent implantation with DES for CAD and completed >1 year of clinical follow-up were enrolled in this study. Patients were divided into the following 2 groups based on treatment formulation, Platless(R) (test formulation, n=211) or Plavix(R) (reference formulation, n=217). The incidence of 1-year major adverse cardiovascular and cerebrovascular event (MACCE) and stent thrombosis (ST) were retrospectively reviewed. RESULTS: The baseline demographic and procedural characteristics were not significantly different between two treatment groups. The incidence of 1-year MACCEs was 8.5% {19/211, 2 deaths, 4 myocardial infarctions (MIs), 2 strokes, and 11 target vessel revascularizations (TVRs)} in Platless(R) group vs. 7.4% (16/217, 4 deaths, 1 MI, 2 strokes, and 9 TVRs) in Plavix(R) group (p=0.66). The incidence of 1-year ST was 0.5% (1 definite and subacute ST) in Platless(R) group vs. 0% in Plavix(R) group (p=0.49). CONCLUSION: In this study, the 2 tablet preparations of clopidogrel showed similar rates of MACCEs, but additional prospective randomized studies with pharmacodynamics and platelet reactivity are needed to conclude whether generic clopidgrel may replace original clopidogrel.
