Serial Plasma Levels of Angiogenic Factors in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
10.4070/kcj.2012.42.7.464
- Author:
Bo Hyun KIM
1
;
Young Guk KO
;
Ae Young HER
;
Jung Sun KIM
;
Ki Chul HWANG
;
Dong Ho SHIN
;
Byeong Keuk KIM
;
Donghoon CHOI
;
Jong Won HA
;
Myeong Ki HONG
;
Yangsoo JANG
Author Information
1. Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea. ygko@yuhs.ac
- Publication Type:Original Article
- Keywords:
Myocardial infarction;
Angiogenesis modulating agents;
Vascular endothelial growth factor;
Angiopoietin-2
- MeSH:
Angiogenesis Inducing Agents;
Angiogenesis Modulating Agents;
Angiopoietin-2;
Humans;
Incidence;
Ischemia;
Myocardial Infarction;
Percutaneous Coronary Intervention;
Plasma;
Receptors, Vascular Endothelial Growth Factor;
Stroke Volume;
Vascular Endothelial Growth Factor A
- From:Korean Circulation Journal
2012;42(7):464-470
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Patients with acute myocardial infarction show varying degrees of collateral development. However, the relationships between angiogenic factors and degree of collaterals are not well known. SUBJECTS AND METHODS: Fifty-nine patients (mean age, 59+/-10 years) with ST-segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI). Patients were divided into one of 2 groups: group I (Rentrop collateral grade 0/1, n=34) or group II (grade 2/3, n=25). Plasma levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor (sFlt-1), angiopoietin (Ang)-2, and soluble Tie-2 at baseline, 24 and 48 hours after PCI were measured. RESULTS: There were fewer diabetic patients and higher incidence of previous angina and multi-vessel disease in group II. Group II had a lower left ventricular ejection fraction and a trend toward longer pain-to-balloon time. Plasma levels of Ang-2, sFlt-1 were elevated prior to primary PCI and decreased after PCI, whereas plasma level of VEGF was relatively low initially, however rose after PCI. sTie-2 levels showed no significant interval change in group I, but decreased over time in group II. VEGF, sFlt-1, and Tie-2 levels did not differ between the groups at each time point. However, plasma levels of Ang-2 were higher in group I than in group II at baseline and at 48 hours. CONCLUSION: Presence of collaterals in STEMI patients undergoing primary PCI was associated with lesser rise in Ang-2 plasma level. VEGF showed a delayed response to acute ischemia compared to Ang-2. Clinical implications of our findings need to be investigated in further studies.
