Application of arterial spin labeling techniques in autism spectrum disorder with or without global developmental delay
10.3969/j.issn.1002-1671.2024.03.023
- VernacularTitle:动脉自旋标记技术在孤独症谱系障碍伴或不伴全面发育迟缓中的应用
- Author:
Yanyong SHEN
1
;
Xin ZHAO
;
Chi QIN
;
Meiying CHENG
;
Hongrui REN
;
Yongbing SUN
;
Xiaoxue ZHANG
;
Changhao WANG
;
Xiao'an ZHANG
Author Information
1. 郑州大学第三附属医院医学影像科,河南 郑州 450052
- Keywords:
autism spectrum disorder;
global developmental delay;
arterial spin labeling;
cerebral blood flow
- From:
Journal of Practical Radiology
2024;40(3):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure and compare the cerebral blood flow(CBF)of children with autism spectrum disorder(ASD),global developmental delay(GDD),and ASD with GDD groups via arterial spin labeling(ASL)technique,and to evaluate the diag-nostic value of CBF values.Methods ASL images of ASD,GDD,and ASD with GDD groups of children were firstly acquired,and the CBF values of frontal lobe,temporal lobe,parietal lobe,occipital lobe,striatum and thalamus region of interest(ROI)were fur-ther measured,respectively.One-way analysis of variance or Kruskal-Wallis H test was used to compare the differences in CBF values among these three groups,and the receiver operating characteristic(ROC)curve was used to analyze the efficacy of CBF values in distinguishing ASD with GDD from without GDD.Results ASD with GDD had significantly lower CBF values in the left and right frontal lobes than those with ASD or GDD alone,and the differences were statistically significant(P<0.05).The CBF values in the left and right frontal lobes effectively distinguished ASD with GDD from without GDD[area under the curve(AUC)>0.7].Conclusion ASL technique can noninvasively assess CBF in children with or without GDD,helping to understand the pathophysiology of ASD with GDD and improving diagnostic accuracy.
