The value of exponential apparent diffusion coefficient value in predicting progression-free survival in patients with FIGO stage Ⅰ/Ⅱ cervical cancer
10.3969/j.issn.1002-1671.2024.03.014
- VernacularTitle:指数化表观扩散系数值在预测FIGO Ⅰ/Ⅱ期宫颈癌患者无进展生存期中的价值
- Author:
Wanxu REN
1
;
Lei DENG
;
Ali SHANG
;
Zhiwen CHE
;
Jinman ZHONG
;
Quanxin YANG
Author Information
1. 陕西中医药大学医学技术学院,陕西 咸阳 712046
- Keywords:
cervical cancer;
progression-free survival;
recur-rence;
diffusion weighted imaging
- From:
Journal of Practical Radiology
2024;40(3):402-405,421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between exponential apparent diffusion coefficient(eADC)value before radical hysterectomy and postoperative clinical results in patients with International Federation of Gynecology and Obstetrics(FIGO)stageⅠ/Ⅱ cervical cancer,and to find MR quantitative indicators for predicting the prognosis of patients with early stage cervical cancer.Methods Patients with FIGO stage Ⅰ/Ⅱ cervical cancer who underwent surgical treatment were retrospectively collected.All patients underwent MRI plain scan and diffusion weighted imaging(DWI)scan before surgery.Baseline parameters included age,menopause,stage,tumor size,pathological differentiation and type,lymph node involvement,and postoperative adjuvant therapy.MR parameters included mean apparent diffusion coefficient(ADCmean),normalized apparent diffusion coefficient(nADC),eADC,SIDWI,and SIT2.Baseline and MRI parameters associated with recurrence were determined by Cox regression analysis.Results The progression-free survival(PFS)in the low eADC group was longer than that in the high eADC group(P=0.010).Univariate analysis showed that ADC,nADC and eADC were associated with recurrence(P<0.05).In multivariate analysis,only eADC[hazard ratio(HR)3.610;95%confidence interval(CI)1.467-8.886;P=0.005]was associated with recurrence.Conclusion Preoperative eADC is associated with PFS in patients with surgically treated FIGO stage Ⅰ/Ⅱ cervical cancer and is helpful in evaluating the prognosis of patients with cervical cancer.
