Prediction of liver failure in patients with hepatocellular carcinoma after extensive resection by functional liver imaging score
10.3969/j.issn.1002-1671.2024.02.012
- VernacularTitle:肝脏功能影像评分预测肝细胞癌大范围切除术后肝衰竭的应用价值
- Author:
Xiangyang HUANG
1
;
Yunying QIN
;
Lei HUANG
;
Lijuan LIU
;
Ningbin LUO
Author Information
1. 广西医科大学附属肿瘤医院放射科,广西 南宁 530021
- Keywords:
hepatocellular carcinoma;
gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid;
magnetic resonance imaging;
imaging score;
post-hepatectomy liver failure
- From:
Journal of Practical Radiology
2024;40(2):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive value of functional liver imaging score(FLIS)based on preoperative gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced MRI for post-hepatectomy liver failure(PHLF)in patients with hepatocellular carcinoma(HCC).Methods The data of HCC patients who underwent extensive hepatectomy and preoperative Gd-EOB-DTPA enhanced MRI were analyzed retrospectively.The FLIS was scored based on the three features including liver parenchyma enhancement,biliary excretion and portal vein signal enhancement in hepatobiliary phase images,and the consistency between different observers was evaluated.Logistic regression model and receiver operating characteristic(ROC)curve were used to analyze the ability of FLIS to predict the PHLF.Results PHLF occurred in 29 of 120 HCC patients(24.2%).The intraclass correlation coefficient(ICC)of FLIS evaluated by two observers was 0.944.Multivariate logistic regression analysis showed that FLIS was an independent predictor of PHLF of HCC patients[odds ratio(OR)0.520,95%confidence interval(CI)0.355-0.726;P<0.001].The area under the curve(AUC)of FLIS for predicting the PHLF was 0.709,the optimal diagnostic threshold was 4,and the corresponding sensitivity and specificity were 78.0%and 58.6%.Conclusion Preoperative FLIS can predict the PHLF of HCC patients,which may help to make more accurate treatment plans for HCC patients.
