Study on the correlation between cerebral glymphatic system dysfunction and motor dysfunction in patient with ischemic stroke
10.3969/j.issn.1002-1671.2023.12.003
- VernacularTitle:缺血性卒中脑类淋巴系统功能受损与运动功能障碍的相关性研究
- Author:
Juan TIAN
1
;
Xin LI
;
Xiaoshi LI
;
Yifan QIAN
;
Xiaohua GAO
;
Lei WANG
;
Yue QIN
Author Information
1. 西安大兴医院影像科,陕西 西安 710016
- Keywords:
cerebral glymphatic system;
ischemic stroke;
motor dysfunction;
diffusion tensor imaging
- From:
Journal of Practical Radiology
2023;39(12):1922-1925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the activity of the cerebral glymphatic system during recovery in ischemic stroke(IS)patients with motor dysfunction,and to explore its association with motor function scores and corticospinal tract(CST)integrity via.Methods A total of 20 patients with IS(stroke group)and 20 healthy volunteer(control group)were recruited.There was a single lesion located at the left cerebral hemisphere in the stroke group.Demographic and clinical data of all participants were recorded.All participants underwent brain MRI scans,including diffusion tensor imaging(DTI)and T2WI.Diffusion tensor image analysis along the perivascular space(DTI-ALPS)index at lateral ventricle level,fractional anisotropy(FA)and axial diffusivity(AD)of CST were calculated and the differences of each index between the two groups were compared.The correlation between DTI-ALPS index and Fugl-Meyer score and integrity of CST were analyzed in stroke group,respectively.Results The DTI-ALPS index in the stroke group was significantly lower than that in the control group(t=-3.88,P＜0.001).The DTI-ALPS index in the stroke group was positively correlated with motor function score(P=0.019),motor function grading(P=0.024)and sensory score(P=0.048),respectively.The DTI-ALPS index was negatively correlated with FA(r=-0.60,P=0.009)and AD(r=-0.67,P=0.002)of healthy side CST.Conclusion The decrease of DTI-ALPS index in patients with IS indicates the damage of cerebral glymphatic system.DTI-ALPS index may be a potential MRI biomarker for motor dysfunction in patients with IS,and a new idea is proposed for the study of the pathophysiological mechanism of IS.
