The Association between Ophthalmic Artery Doppler Variables and the Severi-ty of Pre-eclampsia:a Meta-analysis
- VernacularTitle:眼动脉多普勒超声指标与子痫前期严重程度关系的荟萃分析
- Author:
Li DAI
1
;
Xiaohong WEI
;
Lingyun LIAO
;
Yangxue YIN
;
Qin XU
;
Shuangshuang XIE
;
Rong ZHOU
Author Information
1. 四川大学华西第二医院妇产科出生缺陷与相关妇儿疾病教育部重点实验室国家卫生健康委员会时间生物学重点实验室,四川成都 610041
- Keywords:
Ophthalmic artery;
Doppler ultrasound;
Pre-eclampsia;
Meta-analysis
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(2):153-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between the Doppler variables of the ophthalmic artery with the severity of preeclampsia(PE).Methods:Systematic literature was searched between January 1995 and March 2023 in PubMed,Web of Science,Embase,and the Cochrane Library.Studies comparing ophthalmic artery Doppler variables,including peak systolic velocity(PSV),end-diastolic velocity(EDV),resistive index(Rl),pulsa-tility index(PI),and peak ratio(PR,the ratio of the flow velocity of the second peak to that of the initial peak)in patients with PE,severe preeclampsia(sPE),and healthy pregnant women were included.The random-effects model was adopted as the method of pooled analysis,and the I2value was used to assess heterogeneity.The pooled standardized mean difference(SMD)with 95％confidence interval(CI)was used to estimate the associa-tion between ophthalmic artery Doppler variables and PE patient's characteristics.Results:Eight retrospective studies were eventually included in this Meta-analysis.Our pooled results suggested that compared with PE ca-ses,sPE patients had lower PI levels(SMD-0.56,95％CI-0.92～-0.20,P=0.000),higher EDV levels(SMD 0.47,95％CI 0.12～0.83,P=0.028)and higher PR levels(SMD0.96,95％CI 0.13～1.78,P=0.023).Howev-er,there was no significant difference between PE and sPE patients about the PSV and RI(P=0.361,P=0.626).Conclusions:This review demonstrates that ophthalmic artery Doppler variables(PI,EDV and PR)could be useful for predicting PE and PE development(especially in identifying sPE),which in turn may help the practitioner in the management of these complicated cases and in taking early necessary precautions.
