Research progress in animal models for tic disorder
10.3760/cma.j.cn101070-20231024-00301
- VernacularTitle:抽动障碍实验动物研究进展
- Author:
Zhongling KE
1
;
Yanhui CHEN
Author Information
1. 福建医科大学附属协和医院儿科，福州 350000
- Keywords:
Animal model;
Tic disorder;
Cause;
Pathogenesis
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(4):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Tic disorder (TD) is a neurodevelopmental disorder that occurs in childhood, characterized by involuntary movements or vocal tics and occasionally accompanied by various comorbidities.It may seriously affect children′s daily life, learning and social activities.Exploring its etiology and pathological mechanisms and developing drugs require extensive research on animal models.There are currently various methods for constructing TD models, including induced and spontaneous animal models, such as induced animal models with abnormal neurotransmitters and immune functions and spontaneous animal models based on genetic engineering.However, no animal model can fully match the manifestations of TD.This article summarizes the commonly used animal models for TD to provide references for exploring pathological mechanisms and developing drugs.
