Type 2 inflammatory diseases: a new pattern of Group 2 innate lymphoid cells-dendritic cells-T helper 2 cells and advances in targeted drug therapies
10.3760/cma.j.cn101070-20230521-00400
- VernacularTitle:2型炎症性疾病：2型固有淋巴样细胞-树突状细胞-2型辅助性T细胞的新模式及靶向药物治疗进展
- Author:
Pingping WANG
1
;
Shenggang DING
Author Information
1. 安徽医科大学第一附属医院儿科，合肥 230000
- Keywords:
Type 2 immunity;
Type 2 inflammation;
T helper 2 cells;
Group 2 innate lymphoid cells;
Target therapy
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the discovery of Group 2 innate lymphoid cells(ILC2) has expanded the understanding of type 2 immunity and promoted the birth of the concept of type 2 inflammation.Type 2 inflammation is an inflammatory reaction mediated by both innate and adaptive immunity.It is mainly involved by ILC2 cells and T helper 2 cells and is characterized by upregulation of type 2 cytokines and IgE-mediated release of inflammatory mediators and barrier dysfunction.Due to the common intrinsic mechanism, several kinds of type 2 inflammatory diseases always coexist in the same person, and their prevalence rate and severity continue to rise among children and adolescents, placing a heavy burden on them and their families.This review summarizes the recent development in understanding the mechanism of type 2 immune response and the pathophysiological mechanism of type 2 inflammatory diseases, emphasize the importance of ILC2 and summarize some targeted biologics used in the treatment of related diseases, so as to have a more systematic, comprehensive and in-depth understanding of type 2 inflammation.
